Det er Michael Ironside der lægger stemme til Darkseid der en klassisk superskurk som Justice League ofte kæmper mod. Spillet udkommer 16. oktober. Nedenfor har vi sakset listen med skuespillere der lægger stemme til de forskellige skurke.
In addition to Ironside as Darkseid, LEGO® DC Super-Villains features a stellar voice-over cast, including Mark Hamill (The Joker), Kevin Conroy (Batman), Fred Tatasciore (Clayface, Doomsday, Killer Croc), Gina Torres (Superwoman), Brandon Routh (Shazam), Gilbert Gottfried (Mister Mxyzptlk), Mark Rolston (Deathstroke), Scott Porter (Aquaman), Julie Nathanson (Silver Banshee), Michael Rosenbaum (Flash), Tara Strong (Harley Quinn), C. Thomas Howell (Reverse-Flash), Cissy Jones(Lois Lane), Clancy Brown (Lex Luthor), Wally Wingert (Riddler), Tasia Valenza (Poison Ivy), Tom Kane(Commissioner Gordon), Lex Lang (Deathstorm), Travis Willingham (Superman), JB Blanc (Penguin, Ra’s al Ghul) and Eric Bauza (Mister Freeze), among many others.